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KMID : 1023920170190030001
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Journal of the Korean Academy of Kinesiology
2017 Volume.19 No. 3 p.1 ~ p.13
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Health and Fitness| Changes in Muscle Biomarkers Following Swimming Exercise in Streptozotocin-induced Rats
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Kim Young-Sik
Reid Storm N. S.
Park Eun-Kee
Ahn Yeh-Chan
Jeon Byeong-Hwan
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Abstract
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PURPOSE: The purpose of this study was to assess the effect of swimming exercise in diabetic atrophy by monitoring changes in biomarkers associated with musculoskeletal growth and abnormalities.
METHODS: Ninety-two male Sprague-Dawley rats were randomly divided into four groups: control plus exercise group (CO+Ex), control and no exercise group (CO+No Ex), diabetes plus exercise group (DM+Ex) and diabetes and no exercise group (DM+No Ex). Swimming exercise was implemented for 60 min/day, 5 day/week for a total of eight weeks. Muscle strength and atrophy biomarkers as well as muscle morphology were compared at the first, second, fourth and eighth week of experimentation.
RESULTS: ACE levels were significantly higher in the DM groups (p<.05), however swimming exercise did not significantly affect ACE levels. Irisin levels were significantly higher in the DM and DM+Ex groups compared to the CON, in week one (p<.05), and greater in the DM+Ex group at week two compared to CON+Ex (p<.05), but swimming did not significantly affect irisin levels over the eight-week period in DM rats. In terms of muscle damage, Myl3 expression was unchanged in the CON groups, but significantly higher in the DM+Ex group compared to the CON+Ex group (p<.05). AST was found to be in higher levels in the DM+No Ex group, compared to CON and CON+Ex (p<.05); and DM+Ex group, compared to the CON+Ex group at weeks one, four and eight (p<.05). Tibialis anterior muscle fibers were thicker in the DM+Ex group compared to DM+No Ex, but only at week four (p<.05). Otherwise, no other notable differences were recorded in muscle morphology.
CONCLUSIONS: These results suggest that swimming exercise alone may not be sufficient to induce muscle strength and/or protective effects against muscle atrophy associated with diabetes mellitus. However, this mode of exercise may be considered safe by not compounding the deteriorative effects of this disease.
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KEYWORD
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atrophy, AST, ACE, irisin, myl3
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